BDBM50421126 CHEMBL2088585

SMILES: Fc1ccc(Oc2ccc3c(-c4ccccc4F)c(=O)ccn3n2)c(F)c1

InChI Key: InChIKey=SWPXGFWJBPCQJS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50421126   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase p38 beta (Mus musculus (mouse))	BDBM50421126 (CHEMBL2088585) Show SMILES Fc1ccc(Oc2ccc3c(-c4ccccc4F)c(=O)ccn3n2)c(F)c1 |(32.52,-8.2,;32.51,-6.66,;31.17,-5.89,;31.17,-4.35,;32.5,-3.58,;32.5,-2.04,;31.16,-1.27,;31.15,.27,;29.82,1.02,;28.5,.25,;27.17,1.02,;27.17,2.56,;28.51,3.33,;28.5,4.88,;27.17,5.64,;25.84,4.87,;25.84,3.33,;24.5,2.56,;25.84,.25,;24.5,1.02,;25.84,-1.29,;27.17,-2.06,;28.51,-1.28,;29.83,-2.04,;33.84,-4.34,;35.16,-3.56,;33.85,-5.88,)| Show InChI InChI=1S/C20H11F3N2O2/c21-12-5-7-18(15(23)11-12)27-19-8-6-16-20(13-3-1-2-4-14(13)22)17(26)9-10-25(16)24-19/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012) Article DOI: 10.1016/j.bmcl.2012.07.035 BindingDB Entry DOI: 10.7270/Q28P61S0
					More data for this Ligand-Target Pair
MAP kinase p38 (Mus musculus (mouse))	BDBM50421126 (CHEMBL2088585) Show SMILES Fc1ccc(Oc2ccc3c(-c4ccccc4F)c(=O)ccn3n2)c(F)c1 |(32.52,-8.2,;32.51,-6.66,;31.17,-5.89,;31.17,-4.35,;32.5,-3.58,;32.5,-2.04,;31.16,-1.27,;31.15,.27,;29.82,1.02,;28.5,.25,;27.17,1.02,;27.17,2.56,;28.51,3.33,;28.5,4.88,;27.17,5.64,;25.84,4.87,;25.84,3.33,;24.5,2.56,;25.84,.25,;24.5,1.02,;25.84,-1.29,;27.17,-2.06,;28.51,-1.28,;29.83,-2.04,;33.84,-4.34,;35.16,-3.56,;33.85,-5.88,)| Show InChI InChI=1S/C20H11F3N2O2/c21-12-5-7-18(15(23)11-12)27-19-8-6-16-20(13-3-1-2-4-14(13)22)17(26)9-10-25(16)24-19/h1-11H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay				Bioorg Med Chem Lett 22: 5979-83 (2012) Article DOI: 10.1016/j.bmcl.2012.07.035 BindingDB Entry DOI: 10.7270/Q28P61S0
					More data for this Ligand-Target Pair