Found 15 hits for monomerid = 50425123 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE5A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Phosphodiesterase Type 10 (PDE10A)
(Rattus norvegicus (rat)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
Curated by ChEMBL
| Assay Description Inhibition of rat PDE10A expressed in Sf9 cells incubated for 60 mins using [3H]-cAMP substrate by scintillation counting method |
ACS Med Chem Lett 5: 1049-53 (2014)
Article DOI: 10.1021/ml500262u BindingDB Entry DOI: 10.7270/Q2QN68DN |
More data for this Ligand-Target Pair | |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.8 | 25 |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description Human recombinant PDE2A (hPDE2A) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of inf... |
US Patent US9669035 (2017)
BindingDB Entry DOI: 10.7270/Q2Z60M6H |
More data for this Ligand-Target Pair | |
Phosphodiesterase Type 10 (PDE10A)
(Rattus norvegicus (rat)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | 7.8 | 25 |
JANSSEN PHARMACEUTICA NV
US Patent
| Assay Description Rat recombinant PDE10A (rPDE10A2) was expressed in Sf9 cells using a recombinant rPDE10A baculovirus construct. Cells were harvested after 48 h of in... |
US Patent US9669035 (2017)
BindingDB Entry DOI: 10.7270/Q2Z60M6H |
More data for this Ligand-Target Pair | |
Phosphodiesterase Type 10 (PDE10A)
(Rattus norvegicus (rat)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE3B expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Phosphodiesterase 11A (PDE11A)
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE11A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE10A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Phosphodiesterase 9A
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE9A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Phosphodiesterase 7
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE7A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE4A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Phosphodiesterase 3 (PDE3)
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE3A expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen-Cilag S.A.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant PDE1B expressed in Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 23: 785-90 (2013)
Article DOI: 10.1016/j.bmcl.2012.11.077 BindingDB Entry DOI: 10.7270/Q2C82BMR |
More data for this Ligand-Target Pair | |
Homo sapiens phosphodiesterase 2A (PDE2A)
(Homo sapiens (Human)) | BDBM50425123
(CHEMBL2313234 | US9669035, B-3)Show SMILES Cc1nc2ccc(CN3CCOCC3)cc2n2c(nnc12)-c1ccccc1Cl Show InChI InChI=1S/C21H20ClN5O/c1-14-20-24-25-21(16-4-2-3-5-17(16)22)27(20)19-12-15(6-7-18(19)23-14)13-26-8-10-28-11-9-26/h2-7,12H,8-11,13H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV
Curated by ChEMBL
| Assay Description Inhibition of human PDE2A expressed in Sf9 cells incubated for 40 mins using [3H]-cGMP substrate by scintillation counting method |
ACS Med Chem Lett 5: 1049-53 (2014)
Article DOI: 10.1021/ml500262u BindingDB Entry DOI: 10.7270/Q2QN68DN |
More data for this Ligand-Target Pair | |