BDBM50425380 CHEMBL2316195

SMILES: CN1CCN(CCCNC(=O)c2ccc3CCc4cc(Nc5ccc(F)cc5F)ccc4C(=O)c3c2)CC1

InChI Key: InChIKey=CSVJAHBRJPAYIS-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50425380   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50425380 (CHEMBL2316195) Show SMILES CN1CCN(CCCNC(=O)c2ccc3CCc4cc(Nc5ccc(F)cc5F)ccc4C(=O)c3c2)CC1 Show InChI InChI=1S/C30H32F2N4O2/c1-35-13-15-36(16-14-35)12-2-11-33-30(38)22-6-4-20-3-5-21-17-24(8-9-25(21)29(37)26(20)18-22)34-28-10-7-23(31)19-27(28)32/h4,6-10,17-19,34H,2-3,5,11-16H2,1H3,(H,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
University of T£bingen Curated by ChEMBL					Assay Description Inhibition of p38alpha MAP kinase (unknown origin) by ELISA				J Med Chem 56: 241-53 (2013) Article DOI: 10.1021/jm301539x BindingDB Entry DOI: 10.7270/Q2TB187B
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50425380 (CHEMBL2316195) Show SMILES CN1CCN(CCCNC(=O)c2ccc3CCc4cc(Nc5ccc(F)cc5F)ccc4C(=O)c3c2)CC1 Show InChI InChI=1S/C30H32F2N4O2/c1-35-13-15-36(16-14-35)12-2-11-33-30(38)22-6-4-20-3-5-21-17-24(8-9-25(21)29(37)26(20)18-22)34-28-10-7-23(31)19-27(28)32/h4,6-10,17-19,34H,2-3,5,11-16H2,1H3,(H,33,38)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
University of T£bingen Curated by ChEMBL					Assay Description Inhibition of p38alpha MAP kinase in whole blood (unknown origin) assessed as lipopolysaccharide-stimulated TNF-alpha release by ELISA				J Med Chem 56: 241-53 (2013) Article DOI: 10.1021/jm301539x BindingDB Entry DOI: 10.7270/Q2TB187B
					More data for this Ligand-Target Pair