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SMILES: Fc1cc(F)cc(Nc2c(cnc3[nH]c(cc23)-c2ccc(cc2)N2CCOCC2)C(F)(F)F)c1

InChI Key: InChIKey=UUUWGYOSJVGVMJ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50425678   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Focal adhesion kinase 1


(Homo sapiens (Human))		BDBM50425678
PNG
(CHEMBL2315567)
Show SMILES Fc1cc(F)cc(Nc2c(cnc3[nH]c(cc23)-c2ccc(cc2)N2CCOCC2)C(F)(F)F)c1
Show InChI InChI=1S/C24H19F5N4O/c25-15-9-16(26)11-17(10-15)31-22-19-12-21(32-23(19)30-13-20(22)24(27,28)29)14-1-3-18(4-2-14)33-5-7-34-8-6-33/h1-4,9-13H,5-8H2,(H2,30,31,32)
PDB
MMDB

NCI pathway
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KEGG

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PC cid
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Article
PubMed
n/an/a 640n/an/an/an/an/an/a



Merck Serono Research

Curated by ChEMBL


Assay Description
Inhibition of FAK (unknown origin) using biotinylated His-TEV-hsFAK(31-686)(K454R) substrate after 2 hrs by scintillation counting analysis

J Med Chem 56: 1160-70 (2013)


Article DOI: 10.1021/jm3016014
BindingDB Entry DOI: 10.7270/Q2GT5PGP
More data for this
Ligand-Target Pair