BDBM50425807 CHEMBL2316902
SMILES: OC(=O)c1cc2c(C#Cc3cccc(c3)C(F)(F)F)c(oc2cc1O)-c1ccccc1
InChI Key: InChIKey=BEVZTTHCKAIJNU-UHFFFAOYSA-N
Data: 18 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Receptor-type tyrosine-protein phosphatase gamma (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPgamma (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of N-terminal 6xHis-tagged LYP catalytic domain (1 to 303) (unknown origin) expressed in Escherichia coli BL21(DE3) using pNPP as substrat... | J Med Chem 56: 4990-5008 (2013) Article DOI: 10.1021/jm400248c BindingDB Entry DOI: 10.7270/Q2N017XW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine phosphatase alpha (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPalpha (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein phosphatase CDC14A (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of CDC14A (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Low molecular weight phosphotyrosine protein phosphatase (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LMWPTP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein phosphatase VHX (VHX) (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of VHX (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Laforin (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of Laforin (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hematopoietic protein-tyrosine phosphatase (HEPTP) (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of HEPTP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Fas-associated protein-tyrosine phosphatase 1 (FAP1) (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of FAP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein phosphatase (VHR) (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of VHR (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Leukocyte common antigen (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of CD45 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine phosphatase MEG2 (PTP-Meg2) (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTPMEG2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LYP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 11 (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP2 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine phosphatase 1C (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of SHP1 (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein phosphatase non-receptor type 2 (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of TCPTP (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein-tyrosine phosphatase 1B (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of PTP1B (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-type tyrosine-protein phosphatase F (LAR) (Homo sapiens (Human)) | BDBM50425807 (CHEMBL2316902) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine Curated by ChEMBL | Assay Description Inhibition of LAR (unknown origin) expressed in Escherichia coli using pNPP substrate after 5 mins by spectrophotometric analysis | J Med Chem 56: 832-42 (2013) Article DOI: 10.1021/jm301781p BindingDB Entry DOI: 10.7270/Q2KK9D4X | |||||||||||
More data for this Ligand-Target Pair |