BDBM50426573 CHEMBL2324349::US9434711, 306
SMILES: Cc1c(sc2ccccc12)N(Cc1ccc(F)c(c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI Key: InChIKey=PIHSZIXJTORHOL-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | 37 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description The functional activity of compounds of the formula (I) was determined by measuring changes in intracellular calcium concentration using a Ca2+-sensi... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Rattus norvegicus (Rat)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of TRPM8 (unknown origin) | J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica, N.V. US Patent | Assay Description For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential M8 protein (Canis lupus familiaris (Dog)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica, N.V. US Patent | Assay Description For patch clamp experiments, HEK293 cells are stably transfected with canine TRPM8 and cultured in DMEM supplemented with 10% fetal bovine serum, 100... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human)) | BDBM50426573 (CHEMBL2324349 | US9434711, 306) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | 25 |
Janssen Pharmaceutica, N.V. US Patent | Assay Description For functional expression of TRPM8, the full-length cDNA encoding human and rat TRPM8 are subcloned into pCI-NEO mammalian expression vectors. The ex... | US Patent US9434711 (2016) BindingDB Entry DOI: 10.7270/Q2H41QB6 | |||||||||||
More data for this Ligand-Target Pair |