Found 4 hits for monomerid = 50426931 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50426931
(CHEMBL2323729)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Basic Science Institute
Curated by ChEMBL
| Assay Description Inhibition of HA-EGFP tagged Plk1 polo-box domain (unknown origin) expressed in 293A cells assessed as inhibition of biotin-p-T78 binding after 1 hr ... |
Bioorg Med Chem 21: 2623-34 (2013)
Article DOI: 10.1016/j.bmc.2013.02.020 BindingDB Entry DOI: 10.7270/Q2J38TZ4 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50426931
(CHEMBL2323729)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 1.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50426931
(CHEMBL2323729)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PLK1
(Homo sapiens (Human)) | BDBM50426931
(CHEMBL2323729)Show SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)OP(O)(O)=O)C(O)=O |r| Show InChI InChI=1S/C26H42N7O12P/c1-13(2)8-17(30-25(39)20-6-5-7-33(20)15(4)35)22(36)29-18(9-16-10-27-12-28-16)23(37)31-19(11-34)24(38)32-21(26(40)41)14(3)45-46(42,43)44/h10,12-14,17-21,34H,5-9,11H2,1-4H3,(H,27,28)(H,29,36)(H,30,39)(H,31,37)(H,32,38)(H,40,41)(H2,42,43,44)/t14-,17+,18+,19+,20+,21+/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo
Curated by ChEMBL
| Assay Description Inhibition of Plk1 polo-box domain in human HeLa cells/biotin-GGGGG-PLHSpT interaction incubated for 30 mins measured after 60 mins by ELISA |
Bioorg Med Chem 21: 608-17 (2013)
Article DOI: 10.1016/j.bmc.2012.11.054 BindingDB Entry DOI: 10.7270/Q2QZ2C94 |
More data for this Ligand-Target Pair | |