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SMILES: CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)C[C@@H]2C[C@@H]2C1

InChI Key: InChIKey=NBSHHMOAKVDMBL-GWTOYCKXSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50427178   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium- and chloride-dependent glycine transporter 1


(Homo sapiens (Human))		BDBM50427178
PNG
(CHEMBL2324486)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)C1(CNC(=O)c2c(F)cccc2F)C[C@@H]2C[C@@H]2C1 |r|
Show InChI InChI=1S/C21H29F2N3O3S/c1-2-10-30(28,29)26-8-6-25(7-9-26)21(12-15-11-16(15)13-21)14-24-20(27)19-17(22)4-3-5-18(19)23/h3-5,15-16H,2,6-14H2,1H3,(H,24,27)/t15-,16+,21?
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PC cid
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Similars
Article
PubMed
n/an/a 621n/an/an/an/an/an/a



AMRI

Curated by ChEMBL


Assay Description
Inhibition of GlyT1a in human JAR cells assessed as inhibition of [3H]glycine uptake by scintillation proximity assay

Bioorg Med Chem Lett 23: 1257-61 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.006
BindingDB Entry DOI: 10.7270/Q2WH2RB6
More data for this
Ligand-Target Pair