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BDBM50427797 CHEMBL2325188

SMILES: N[C@H]1CC[C@H](CCCNC(=O)Nc2ccc3nnsc3c2)CC1

InChI Key: InChIKey=YAJXXTKUZFMGHV-HAQNSBGRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50427797   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein arginine methyltransferase 3 (PRMT3)


(Homo sapiens (Human))		BDBM50427797
PNG
(CHEMBL2325188)
Show SMILES N[C@H]1CC[C@H](CCCNC(=O)Nc2ccc3nnsc3c2)CC1 |r,wU:4.4,wD:1.0,(21.99,-11.24,;20.66,-10.47,;20.66,-8.93,;19.33,-8.15,;18,-8.92,;16.67,-8.16,;15.34,-8.93,;14,-8.16,;12.67,-8.93,;11.34,-8.16,;11.33,-6.62,;10,-8.94,;8.67,-8.17,;8.66,-6.62,;7.33,-5.85,;6,-6.62,;4.53,-6.15,;3.62,-7.4,;4.53,-8.64,;6,-8.17,;7.33,-8.94,;18,-10.47,;19.33,-11.24,)|
Show InChI InChI=1S/C16H23N5OS/c17-12-5-3-11(4-6-12)2-1-9-18-16(22)19-13-7-8-14-15(10-13)23-21-20-14/h7-8,10-12H,1-6,9,17H2,(H2,18,19,22)/t11-,12-
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Article
PubMed
n/an/a 5.30E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of PRMT3 (unknown origin) using histone H4 (1 to 24) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenos...

J Med Chem 56: 2110-24 (2013)


Article DOI: 10.1021/jm3018332
BindingDB Entry DOI: 10.7270/Q2W95BHJ
More data for this
Ligand-Target Pair