BDBM50428993 CHEMBL2333661

SMILES: COc1c(Br)c(O)c(Br)cc1\C=N\NC(=O)c1ccc2cc(Br)ccc2c1

InChI Key: InChIKey=JVXYYUAMAWHCIQ-NUGSKGIGSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50428993   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NAD-Dependent Deacetylase Sirtuin-1 (Homo sapiens (Human))	BDBM50428993 (CHEMBL2333661) Show SMILES COc1c(Br)c(O)c(Br)cc1\C=N\NC(=O)c1ccc2cc(Br)ccc2c1 Show InChI InChI=1S/C19H13Br3N2O3/c1-27-18-13(8-15(21)17(25)16(18)22)9-23-24-19(26)12-3-2-11-7-14(20)5-4-10(11)6-12/h2-9,25H,1H3,(H,24,26)/b23-9+	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.70E+3	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-...				J Med Chem 56: 761-80 (2013) Article DOI: 10.1021/jm301032j BindingDB Entry DOI: 10.7270/Q2XP768M
					More data for this Ligand-Target Pair