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SMILES: Oc1c(Br)cc(\C=N\NC(=O)c2ccc(cc2)-c2ccccn2)c(O)c1Br

InChI Key: InChIKey=MGRZSOWPGNGIBS-AUEPDCJTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50428997   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
NAD-dependent protein deacetylase sirtuin-1


(Homo sapiens (Human))		BDBM50428997
PNG
(CHEMBL2333656)
Show SMILES Oc1c(Br)cc(\C=N\NC(=O)c2ccc(cc2)-c2ccccn2)c(O)c1Br
Show InChI InChI=1S/C19H13Br2N3O3/c20-14-9-13(17(25)16(21)18(14)26)10-23-24-19(27)12-6-4-11(5-7-12)15-3-1-2-8-22-15/h1-10,25-26H,(H,24,27)/b23-10+
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Article
PubMed
n/an/an/an/a 2.30E+3n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Activation of N-terminal His6-tagged SIRT1 (156 to 664 amino acid residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using ac-RHKKac-...

J Med Chem 56: 761-80 (2013)


Article DOI: 10.1021/jm301032j
BindingDB Entry DOI: 10.7270/Q2XP768M
More data for this
Ligand-Target Pair