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SMILES: Cn1cncc1C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1

InChI Key: InChIKey=LACRCQMHQSWGOI-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50429619   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase kinase kinase 14


(Homo sapiens (Human))		BDBM50429619
PNG
(CHEMBL2334585)
Show SMILES Cn1cncc1C#Cc1ccc2[nH]c3CCCc4cnc(N)nc4-c3c2c1
Show InChI InChI=1S/C21H18N6/c1-27-12-23-11-15(27)7-5-13-6-8-17-16(9-13)19-18(25-17)4-2-3-14-10-24-21(22)26-20(14)19/h6,8-12,25H,2-4H2,1H3,(H2,22,24,26)
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KEGG

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Similars
Article
PubMed
n/an/a 3.00E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of NIK (unknown origin) autophosphorylation after 1 hr by chemiluminescent assay

Bioorg Med Chem Lett 23: 1238-44 (2013)


Article DOI: 10.1016/j.bmcl.2013.01.012
BindingDB Entry DOI: 10.7270/Q2J967RQ
More data for this
Ligand-Target Pair