BDBM50429668 CHEMBL2335019

SMILES: CC(C)(C)C(=O)Nc1nc(Nc2ccc(F)c(c2)C(F)(F)F)c2cc(CCc3ccccn3)[nH]c2n1

InChI Key: InChIKey=DIYNUINZCGHYBO-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50429668   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50429668 (CHEMBL2335019) Show SMILES CC(C)(C)C(=O)Nc1nc(Nc2ccc(F)c(c2)C(F)(F)F)c2cc(CCc3ccccn3)[nH]c2n1 Show InChI InChI=1S/C25H24F4N6O/c1-24(2,3)22(36)35-23-33-20-17(12-15(31-20)8-7-14-6-4-5-11-30-14)21(34-23)32-16-9-10-19(26)18(13-16)25(27,28)29/h4-6,9-13H,7-8H2,1-3H3,(H3,31,32,33,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGF-BB-induced PDGFR beta phosphorylation in human SF539 cells overexpressing PDGFR beta pretreated for 60 mins prior to PDGF-BB addit...				Bioorg Med Chem 21: 1312-23 (2013) Article DOI: 10.1016/j.bmc.2012.12.045 BindingDB Entry DOI: 10.7270/Q25140KN
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50429668 (CHEMBL2335019) Show SMILES CC(C)(C)C(=O)Nc1nc(Nc2ccc(F)c(c2)C(F)(F)F)c2cc(CCc3ccccn3)[nH]c2n1 Show InChI InChI=1S/C25H24F4N6O/c1-24(2,3)22(36)35-23-33-20-17(12-15(31-20)8-7-14-6-4-5-11-30-14)21(34-23)32-16-9-10-19(26)18(13-16)25(27,28)29/h4-6,9-13H,7-8H2,1-3H3,(H3,31,32,33,34,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.69E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGF-induced EGFR phosphorylation in human A431 cells overexpressing EGFR pretreated for 60 mins prior to EGF addition measured after 10...				Bioorg Med Chem 21: 1312-23 (2013) Article DOI: 10.1016/j.bmc.2012.12.045 BindingDB Entry DOI: 10.7270/Q25140KN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50429668 (CHEMBL2335019) Show SMILES CC(C)(C)C(=O)Nc1nc(Nc2ccc(F)c(c2)C(F)(F)F)c2cc(CCc3ccccn3)[nH]c2n1 Show InChI InChI=1S/C25H24F4N6O/c1-24(2,3)22(36)35-23-33-20-17(12-15(31-20)8-7-14-6-4-5-11-30-14)21(34-23)32-16-9-10-19(26)18(13-16)25(27,28)29/h4-6,9-13H,7-8H2,1-3H3,(H3,31,32,33,34,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.51E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells overexpressing Flk-1 pretreated for 60 mins prior to VEGF addition measured aft...				Bioorg Med Chem 21: 1312-23 (2013) Article DOI: 10.1016/j.bmc.2012.12.045 BindingDB Entry DOI: 10.7270/Q25140KN
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50429668 (CHEMBL2335019) Show SMILES CC(C)(C)C(=O)Nc1nc(Nc2ccc(F)c(c2)C(F)(F)F)c2cc(CCc3ccccn3)[nH]c2n1 Show InChI InChI=1S/C25H24F4N6O/c1-24(2,3)22(36)35-23-33-20-17(12-15(31-20)8-7-14-6-4-5-11-30-14)21(34-23)32-16-9-10-19(26)18(13-16)25(27,28)29/h4-6,9-13H,7-8H2,1-3H3,(H3,31,32,33,34,35,36)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGF-induced VEGFR1 phosphorylation in human A498 cells overexpressing Flt-1 pretreated for 60 mins prior to VEGF addition measured aft...				Bioorg Med Chem 21: 1312-23 (2013) Article DOI: 10.1016/j.bmc.2012.12.045 BindingDB Entry DOI: 10.7270/Q25140KN
					More data for this Ligand-Target Pair