BDBM50431246 CHEMBL2333062::US9428465, 32
SMILES: CCCCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
InChI Key: InChIKey=WHQYZSQAVZUYNA-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acid ceramidase (AC) (Rattus norvegicus (Rat)) | BDBM50431246 (CHEMBL2333062 | US9428465, 32) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Fondazione Istituto Italiano di Tecnologia Curated by ChEMBL | Assay Description Inhibition of rat recombinant acid ceramidase expressed in human HEK293 cells using N-lauroylceramide as substrate incubated for 30 mins prior to sub... | J Med Chem 56: 3518-30 (2013) Article DOI: 10.1021/jm301879g BindingDB Entry DOI: 10.7270/Q27D2WH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acid ceramidase (AC) (Rattus norvegicus (Rat)) | BDBM50431246 (CHEMBL2333062 | US9428465, 32) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 4.5 | n/a |
Fondazione Istituto Italiano Di Technologia US Patent | Assay Description r-AC protein samples were pre-incubated with various concentrations of test compounds or vehicle control in 100 mM NaH2PO4/citrate buffer pH 4.5, 0.1... | US Patent US9428465 (2016) BindingDB Entry DOI: 10.7270/Q26972GB | |||||||||||
More data for this Ligand-Target Pair |