Found 5 hits for monomerid = 50431377 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50431377
(CHEMBL2347416)Show SMILES CN1CC(Cn2nc(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c3cc(OC(F)F)ccc23)C1 Show InChI InChI=1S/C24H27F2N7O2/c1-24(2,3)30-22(34)16-8-27-21-20(16)29-17(9-28-21)19-15-7-14(35-23(25)26)5-6-18(15)33(31-19)12-13-10-32(4)11-13/h5-9,13,23H,10-12H2,1-4H3,(H,27,28)(H,30,34) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP2D6 (unknown origin) |
J Med Chem 56: 1677-92 (2013)
Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50431377
(CHEMBL2347416)Show SMILES CN1CC(Cn2nc(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c3cc(OC(F)F)ccc23)C1 Show InChI InChI=1S/C24H27F2N7O2/c1-24(2,3)30-22(34)16-8-27-21-20(16)29-17(9-28-21)19-15-7-14(35-23(25)26)5-6-18(15)33(31-19)12-13-10-32(4)11-13/h5-9,13,23H,10-12H2,1-4H3,(H,27,28)(H,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 293 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Inhibition of human ERG channel |
J Med Chem 56: 1677-92 (2013)
Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50431377
(CHEMBL2347416)Show SMILES CN1CC(Cn2nc(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c3cc(OC(F)F)ccc23)C1 Show InChI InChI=1S/C24H27F2N7O2/c1-24(2,3)30-22(34)16-8-27-21-20(16)29-17(9-28-21)19-15-7-14(35-23(25)26)5-6-18(15)33(31-19)12-13-10-32(4)11-13/h5-9,13,23H,10-12H2,1-4H3,(H,27,28)(H,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate asses... |
J Med Chem 56: 1677-92 (2013)
Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50431377
(CHEMBL2347416)Show SMILES CN1CC(Cn2nc(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c3cc(OC(F)F)ccc23)C1 Show InChI InChI=1S/C24H27F2N7O2/c1-24(2,3)30-22(34)16-8-27-21-20(16)29-17(9-28-21)19-15-7-14(35-23(25)26)5-6-18(15)33(31-19)12-13-10-32(4)11-13/h5-9,13,23H,10-12H2,1-4H3,(H,27,28)(H,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Inhibition of SYK in human Ramos cells |
J Med Chem 56: 1677-92 (2013)
Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase SYK
(Homo sapiens (Human)) | BDBM50431377
(CHEMBL2347416)Show SMILES CN1CC(Cn2nc(-c3cnc4[nH]cc(C(=O)NC(C)(C)C)c4n3)c3cc(OC(F)F)ccc23)C1 Show InChI InChI=1S/C24H27F2N7O2/c1-24(2,3)30-22(34)16-8-27-21-20(16)29-17(9-28-21)19-15-7-14(35-23(25)26)5-6-18(15)33(31-19)12-13-10-32(4)11-13/h5-9,13,23H,10-12H2,1-4H3,(H,27,28)(H,30,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 546 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoffmann-La Roche Inc.
Curated by ChEMBL
| Assay Description Inhibition of SYK in human whole blood |
J Med Chem 56: 1677-92 (2013)
Article DOI: 10.1021/jm301720p BindingDB Entry DOI: 10.7270/Q22N53M0 |
More data for this Ligand-Target Pair | |