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BDBM50432099 CHEMBL2349558

SMILES: COc1cc(C)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)cc1C

InChI Key: InChIKey=KCTCWMYRRDHZRX-INIZCTEOSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50432099   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor


(Rattus norvegicus (rat))		BDBM50432099
PNG
(CHEMBL2349558)
Show SMILES COc1cc(C)c(Nc2nc(Cl)cn([C@@H](COCCF)C3CC3)c2=O)cc1C |r|
Show InChI InChI=1S/C20H25ClFN3O3/c1-12-9-17(27-3)13(2)8-15(12)23-19-20(26)25(10-18(21)24-19)16(14-4-5-14)11-28-7-6-22/h8-10,14,16H,4-7,11H2,1-3H3,(H,23,24)/t16-/m0/s1
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Article
PubMed
n/an/a 0.460n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Displacement of [125I]-o-CRF from CRF1 receptor in rat frontal cortex homogenate after 2 hrs by gamma counting

Bioorg Med Chem Lett 23: 2052-5 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.009
BindingDB Entry DOI: 10.7270/Q2DR2WW3
More data for this
Ligand-Target Pair