BDBM50432405 CHEMBL2349012

SMILES: Cn1nc(cc1C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1)C(F)(F)F

InChI Key: InChIKey=BEMLHPGBOUWMOR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50432405   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50432405 (CHEMBL2349012) Show SMILES Cn1nc(cc1C(=O)Nc1cccc(Oc2ccc3nc(NC(=O)C4CC4)cn3n2)c1)C(F)(F)F Show InChI InChI=1S/C22H18F3N7O3/c1-31-15(10-16(29-31)22(23,24)25)21(34)26-13-3-2-4-14(9-13)35-19-8-7-18-27-17(11-32(18)30-19)28-20(33)12-5-6-12/h2-4,7-12H,5-6H2,1H3,(H,26,34)(H,28,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 5 mins by AlphaScreen assay in presence of 10 uM of ATP				Bioorg Med Chem 21: 2333-45 (2013) Article DOI: 10.1016/j.bmc.2013.01.074 BindingDB Entry DOI: 10.7270/Q22B90C1
					More data for this Ligand-Target Pair