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SMILES: OC[C@@H](Nc1ncnc2oc(c(Cl)c12)-c1ccccc1)c1ccccc1

InChI Key: InChIKey=AGULTCXGHPKMCC-OAHLLOKOSA-N

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50432696   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50432696
PNG
(CHEMBL2347968)
Show SMILES OC[C@@H](Nc1ncnc2oc(c(Cl)c12)-c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C20H16ClN3O2/c21-17-16-19(24-15(11-25)13-7-3-1-4-8-13)22-12-23-20(16)26-18(17)14-9-5-2-6-10-14/h1-10,12,15,25H,11H2,(H,22,23,24)/t15-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 589n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human wild type GST-tagged EGFR kinase domain expressed in Sf9 cells by luminescence assay


J Med Chem 56: 3889-903 (2013)


Article DOI: 10.1021/jm400072p
BindingDB Entry DOI: 10.7270/Q27W6DJ5
More data for this
Ligand-Target Pair