Found 10 hits for monomerid = 50432765 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Inosine-5'-monophosphate dehydrogenase (IMPDH)
(Homo sapiens (Human)) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Allergy and Infectious Diseases
Curated by ChEMBL
| Assay Description Inhibition of human IMPDH2 using IMP as substrate by spectrophotometric method |
J Med Chem 61: 4739-4756 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01839 BindingDB Entry DOI: 10.7270/Q29889M0 |
More data for this Ligand-Target Pair | |
GMP reductase 2
(Homo sapiens) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Allergy and Infectious Diseases
Curated by ChEMBL
| Assay Description Inhibition of human GMPR2 using GMP as substrate by spectrophotometric method |
J Med Chem 61: 4739-4756 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01839 BindingDB Entry DOI: 10.7270/Q29889M0 |
More data for this Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of human IMPDH2 |
J Med Chem 56: 4028-43 (2013)
Article DOI: 10.1021/jm400241j BindingDB Entry DOI: 10.7270/Q2GF0VWF |
More data for this Ligand-Target Pair | |
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
(Homo sapiens (Human)) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of human IMPDH2 |
J Med Chem 56: 4028-43 (2013)
Article DOI: 10.1021/jm400241j BindingDB Entry DOI: 10.7270/Q2GF0VWF |
More data for this Ligand-Target Pair | |
Inosine-5-monophosphate dehydrogenase (IMPDH)
(Cryptosporidium parvum) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5... |
J Med Chem 56: 4028-43 (2013)
Article DOI: 10.1021/jm400241j BindingDB Entry DOI: 10.7270/Q2GF0VWF |
More data for this Ligand-Target Pair | |
Inosine-5-monophosphate dehydrogenase (IMPDH)
(Cryptosporidium parvum) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5... |
J Med Chem 56: 4028-43 (2013)
Article DOI: 10.1021/jm400241j BindingDB Entry DOI: 10.7270/Q2GF0VWF |
More data for this Ligand-Target Pair | |
Inosine-5-monophosphate dehydrogenase (IMPDH)
(Cryptosporidium parvum) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5... |
J Med Chem 56: 4028-43 (2013)
Article DOI: 10.1021/jm400241j BindingDB Entry DOI: 10.7270/Q2GF0VWF |
More data for this Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase, probable
(Cryptosporidium parvum) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of Cryptosporidium IMPDH preincubated for 10 mins before substrate addition by spectrophotometry |
ACS Med Chem Lett 5: 846-50 (2014)
Article DOI: 10.1021/ml500203p BindingDB Entry DOI: 10.7270/Q23J3FN3 |
More data for this Ligand-Target Pair | |
Inosine-5'-monophosphate dehydrogenase
(Bacillus anthracis) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB
UniProtKB/TrEMBL
GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of Bacillus anthracis IMPDH preincubated for 10 mins before substrate addition by spectrophotometry |
ACS Med Chem Lett 5: 846-50 (2014)
Article DOI: 10.1021/ml500203p BindingDB Entry DOI: 10.7270/Q23J3FN3 |
More data for this Ligand-Target Pair | |
Inosine-5-monophosphate dehydrogenase (IMPDH)
(Cryptosporidium parvum) | BDBM50432765
(CHEMBL2348794)Show SMILES C[C@H](Nc1cccc(Cl)c1Cl)C(=O)Nc1ccc2oc(nc2c1)-c1ccncc1 |r| Show InChI InChI=1S/C21H16Cl2N4O2/c1-12(25-16-4-2-3-15(22)19(16)23)20(28)26-14-5-6-18-17(11-14)27-21(29-18)13-7-9-24-10-8-13/h2-12,25H,1H3,(H,26,28)/t12-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Brandeis University
Curated by ChEMBL
| Assay Description Inhibition of Cryptosporidium parvum N-terminal His6-tagged IMPDH-mediated NADH production expressed in Escherichia coli BL21(DE3) preincubated for 5... |
J Med Chem 56: 4028-43 (2013)
Article DOI: 10.1021/jm400241j BindingDB Entry DOI: 10.7270/Q2GF0VWF |
More data for this Ligand-Target Pair | |