BDBM50432894 CHEMBL2376648::US9126947, 1
SMILES: C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CCN(C)CC1)c1c(Cl)ccc(F)c1Cl
InChI Key: InChIKey=ONPGOSVDVDPBCY-CQSZACIVSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM50432894 (CHEMBL2376648 | US9126947, 1) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of c-MET (unknown origin) | Bioorg Med Chem Lett 23: 2408-13 (2013) Article DOI: 10.1016/j.bmcl.2013.02.037 BindingDB Entry DOI: 10.7270/Q2TQ62XH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50432894 (CHEMBL2376648 | US9126947, 1) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | 32 |
Xcovery Holding Company LLC US Patent | Assay Description Assays were performed as described in Fabian et al. (2005) Nature Biotechnology, vol. 23, p. 329 and in Karaman et al. (2008) Nature Biotechnology, v... | US Patent US9126947 (2015) BindingDB Entry DOI: 10.7270/Q2T152DH | |||||||||||
More data for this Ligand-Target Pair |