BDBM50434351 CHEMBL2386749::US9446044, 60
SMILES: COC(=N)c1nc2ccc3ncnc(Nc4ccc(O)c(c4)[N+]([O-])=O)c3c2s1
InChI Key: InChIKey=HFJRGZBUEXFBMO-UHFFFAOYSA-N
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human)) | BDBM50434351 (CHEMBL2386749 | US9446044, 60) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.91 | n/a | n/a | n/a | n/a | 7.5 | 25 |
DIAXONHIT US Patent | Assay Description The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit... | US Patent US9446044 (2016) BindingDB Entry DOI: 10.7270/Q2610Z7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-regulated kinases 1B (Homo sapiens (Human)) | BDBM50434351 (CHEMBL2386749 | US9446044, 60) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of recombinant DYRK1B (unknown origin) after 120 mins in presence of [33P]-ATP | ACS Med Chem Lett 4: 502-3 (2013) Article DOI: 10.1021/ml400137s BindingDB Entry DOI: 10.7270/Q2NK3GDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-phosphorylation regulated kinase 1A (Homo sapiens (Human)) | BDBM50434351 (CHEMBL2386749 | US9446044, 60) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Dart Neuroscience LLC Curated by ChEMBL | Assay Description Inhibition of recombinant DYRK1A (unknown origin) after 120 mins in presence of [33P]-ATP | ACS Med Chem Lett 4: 502-3 (2013) Article DOI: 10.1021/ml400137s BindingDB Entry DOI: 10.7270/Q2NK3GDP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual-specificity tyrosine-regulated kinases 1B (Homo sapiens (Human)) | BDBM50434351 (CHEMBL2386749 | US9446044, 60) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.68 | n/a | n/a | n/a | n/a | 7.5 | 25 |
DIAXONHIT US Patent | Assay Description The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit... | US Patent US9446044 (2016) BindingDB Entry DOI: 10.7270/Q2610Z7J | |||||||||||
More data for this Ligand-Target Pair |