BDBM50435215 CHEMBL2392902
SMILES: Cc1nc(nc(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)c1Cl)-c1cccc(Cl)n1
InChI Key: InChIKey=QWODNELMNXBHBK-NRFANRHFSA-N
Data: 2 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Methionine Aminopeptidase Type 1 (MetAP1) (Homo sapiens (Human)) | BDBM50435215 (CHEMBL2392902) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ... | Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Microtubule-associated protein 2 (Homo sapiens (Human)) | BDBM50435215 (CHEMBL2392902) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of human recombinant GST-6XHis-tagged full-length cytosolic METAP2 expressed in cabbage looper BTI-TN-5B1-4 cells using Met-Pro-p-nitroani... | Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X | |||||||||||
More data for this Ligand-Target Pair |