Found 5 hits for monomerid = 50435777 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50435777
(CHEMBL2393163)Show SMILES O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 Show InChI InChI=1S/C21H27N5O3S/c27-20(24-15-17-2-1-10-22-14-17)25-18-3-5-19(6-4-18)30(28,29)26-12-8-21(9-13-26)7-11-23-16-21/h1-6,10,14,23H,7-9,11-13,15-16H2,(H2,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of human full length C-terminal His6-tagged NAMPT expressed in Escherichia coli Rosetta (DE3) cells using nicotinamide as substrate incuba... |
J Med Chem 59: 8345-68 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00697 BindingDB Entry DOI: 10.7270/Q2KW5J0C |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50435777
(CHEMBL2393163)Show SMILES O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 Show InChI InChI=1S/C21H27N5O3S/c27-20(24-15-17-2-1-10-22-14-17)25-18-3-5-19(6-4-18)30(28,29)26-12-8-21(9-13-26)7-11-23-16-21/h1-6,10,14,23H,7-9,11-13,15-16H2,(H2,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Reversible inhibition of CYP2C9 in human liver microsomes using (S)-warfarin as substrate in presence of NADPH by LC-MS/MS analysis |
J Med Chem 59: 8345-68 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00697 BindingDB Entry DOI: 10.7270/Q2KW5J0C |
More data for this Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50435777
(CHEMBL2393163)Show SMILES O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 Show InChI InChI=1S/C21H27N5O3S/c27-20(24-15-17-2-1-10-22-14-17)25-18-3-5-19(6-4-18)30(28,29)26-12-8-21(9-13-26)7-11-23-16-21/h1-6,10,14,23H,7-9,11-13,15-16H2,(H2,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Inhibition of NAMPT (unknown origin) assessed as NAM conversion to NMN preincubated for 15 mins prior to substrate addition measured after 30 mins by... |
Bioorg Med Chem Lett 23: 3531-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.040 BindingDB Entry DOI: 10.7270/Q2DJ5H1D |
More data for this Ligand-Target Pair | |
Cytochrome P450 2C9
(Homo sapiens (Human)) | BDBM50435777
(CHEMBL2393163)Show SMILES O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 Show InChI InChI=1S/C21H27N5O3S/c27-20(24-15-17-2-1-10-22-14-17)25-18-3-5-19(6-4-18)30(28,29)26-12-8-21(9-13-26)7-11-23-16-21/h1-6,10,14,23H,7-9,11-13,15-16H2,(H2,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Inhibition of CYP2C9 in human liver microsomes after 30 mins |
Bioorg Med Chem Lett 23: 3531-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.040 BindingDB Entry DOI: 10.7270/Q2DJ5H1D |
More data for this Ligand-Target Pair | |
Nicotinamide phosphoribosyltransferase
(Homo sapiens (Human)) | BDBM50435777
(CHEMBL2393163)Show SMILES O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 Show InChI InChI=1S/C21H27N5O3S/c27-20(24-15-17-2-1-10-22-14-17)25-18-3-5-19(6-4-18)30(28,29)26-12-8-21(9-13-26)7-11-23-16-21/h1-6,10,14,23H,7-9,11-13,15-16H2,(H2,24,25,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc.
Curated by ChEMBL
| Assay Description Inhibition of NAMPT in human A2780 cells assessed as decrease in cell viability after 72 hrs by SRB assay |
J Med Chem 59: 8345-68 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00697 BindingDB Entry DOI: 10.7270/Q2KW5J0C |
More data for this Ligand-Target Pair | |