Found 4 hits for monomerid = 50436423 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
(Homo sapiens (Human)) | BDBM50436423
(CHEMBL2397014)Show SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1 Show InChI InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27) | PDB
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UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
| PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Inhibition of LRRK2 (unknown origin) |
J Med Chem 58: 6733-46 (2015)
BindingDB Entry DOI: 10.7270/Q20K2BC9 |
More data for this Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
(Homo sapiens (Human)) | BDBM50436423
(CHEMBL2397014)Show SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1 Show InChI InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27) | PDB
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UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Charles River
Curated by ChEMBL
| Assay Description Inhibition of full length wild-type LRRK2 (unknown origin) using biotinylated ezrin/radaxin/meosin peptide as substrate measured after 1 hr |
Bioorg Med Chem Lett 27: 2520-2527 (2017)
Article DOI: 10.1016/j.bmcl.2017.03.098 BindingDB Entry DOI: 10.7270/Q2474D0R |
More data for this Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
(Homo sapiens (Human)) | BDBM50436423
(CHEMBL2397014)Show SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1 Show InChI InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Sydney
Curated by ChEMBL
| Assay Description Inhibition of human recombinant wild type LRRK2 using biotin-LRRKtide as substrate preincubated for 15 mins prior to substrate addition measured afte... |
Bioorg Med Chem Lett 23: 3690-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.086 BindingDB Entry DOI: 10.7270/Q27P90SD |
More data for this Ligand-Target Pair | |
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
(Homo sapiens (Human)) | BDBM50436423
(CHEMBL2397014)Show SMILES COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1 Show InChI InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| PubMed
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Inhibition of LRRK2 G2019S mutant-induced neuronal toxicity in human cortical neurons |
J Med Chem 58: 6733-46 (2015)
BindingDB Entry DOI: 10.7270/Q20K2BC9 |
More data for this Ligand-Target Pair | |