Found 8 hits for monomerid = 50436451 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated P110alpha (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated P110delta (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of N-terminal myristoylated P110beta (unknown origin)-mediated AKT phosphorylation at Ser473 expressed in rat Rat1 cells by ELISA |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of P110delta (unknown origin) using PIP2:PS as substrate by TR-FRET assay |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 (unknown origin) |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of P110beta (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assay |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of P110gamma (unknown origin) using PIP2:PS as substrate by TR-FRET assay |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50436451
(CHEMBL2397199)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(n1)C1(C)CC1 |r| Show InChI InChI=1S/C18H22N6O2S/c1-10-13(11-5-8-20-15(22-11)18(2)6-7-18)27-16(21-10)23-17(26)24-9-3-4-12(24)14(19)25/h5,8,12H,3-4,6-7,9H2,1-2H3,(H2,19,25)(H,21,23,26)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of P110alpha (unknown origin) using L-a-phosphatidylinositol as substrate by luminescence assay |
Bioorg Med Chem Lett 23: 3741-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.007 BindingDB Entry DOI: 10.7270/Q2M046VD |
More data for this Ligand-Target Pair | |