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SMILES: O=C(Nc1ccccc1)Nc1ccc(Nc2ncnc3oc(c(-c4ccccc4)c23)-c2ccccc2)cc1

InChI Key: InChIKey=HMEFOYWOEZKPAT-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50436704   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aurora kinase A


(Homo sapiens (Human))		BDBM50436704
PNG
(CHEMBL2398646)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(Nc2ncnc3oc(c(-c4ccccc4)c23)-c2ccccc2)cc1
Show InChI InChI=1S/C31H23N5O2/c37-31(35-23-14-8-3-9-15-23)36-25-18-16-24(17-19-25)34-29-27-26(21-10-4-1-5-11-21)28(22-12-6-2-7-13-22)38-30(27)33-20-32-29/h1-20H,(H,32,33,34)(H2,35,36,37)
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MMDB

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Similars
Article
PubMed
n/an/a 201n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged Aurora kinase A catalytic domain (123 to 401 amino acids) (unknown origin) expressed in sf9 cells using tetra(LRRWSLG) as su...

J Med Chem 56: 5247-60 (2014)


Article DOI: 10.1021/jm4006059
BindingDB Entry DOI: 10.7270/Q2J104K6
More data for this
Ligand-Target Pair