BDBM50437208 CHEMBL2402735

SMILES: CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F)C(=O)Nc1ccc(C(O)=O)c(F)c1

InChI Key: InChIKey=FHYGQTXLSUSDHS-FQFMIMTMSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50437208   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM50437208 (CHEMBL2402735) Show SMILES CC(C)(C)C[C@@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]1(C#N)c1ccc(Cl)cc1F)C(=O)Nc1ccc(C(O)=O)c(F)c1 |r| Show InChI InChI=1S/C30H26Cl2F3N3O3/c1-29(2,3)13-23-30(14-36,19-10-7-15(31)11-22(19)34)24(18-5-4-6-20(32)25(18)35)26(38-23)27(39)37-16-8-9-17(28(40)41)21(33)12-16/h4-12,23-24,26,38H,13H2,1-3H3,(H,37,39)(H,40,41)/t23-,24-,26+,30-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Binding affinity to GST-tagged MDM2 (unknown origin) assessed as inhibition of interaction with p53 after 1 hr by HTRF assay				J Med Chem 56: 5979-83 (2014) Article DOI: 10.1021/jm400487c BindingDB Entry DOI: 10.7270/Q2V40WMK
					More data for this Ligand-Target Pair