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BDBM50439422 CHEMBL2420542

SMILES: CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccc(C)c(Cl)c2)ccc1C

InChI Key: InChIKey=FEGDABVRKQZXDI-UHFFFAOYSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50439422   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50439422
PNG
(CHEMBL2420542)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccc(C)c(Cl)c2)ccc1C
Show InChI InChI=1S/C17H20ClN3O3S/c1-11-5-7-13(9-15(11)18)19-17(22)20-14-8-6-12(2)16(10-14)25(23,24)21(3)4/h5-10H,1-4H3,(H2,19,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.90E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Bioorg Med Chem Lett 23: 5195-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.002
BindingDB Entry DOI: 10.7270/Q28K7BG1
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens (Human))
BDBM50439422
PNG
(CHEMBL2420542)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccc(C)c(Cl)c2)ccc1C
Show InChI InChI=1S/C17H20ClN3O3S/c1-11-5-7-13(9-15(11)18)19-17(22)20-14-8-6-12(2)16(10-14)25(23,24)21(3)4/h5-10H,1-4H3,(H2,19,20,22)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 6.20E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Bioorg Med Chem Lett 23: 5195-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.002
BindingDB Entry DOI: 10.7270/Q28K7BG1
More data for this
Ligand-Target Pair