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SMILES: COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl

InChI Key: InChIKey=MKTUZAYNCRKLDS-YIXHJXPBSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50439496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50439496 (CHEMBL2418096 | US9169182, J23) Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Inhibition of recombinant Staphylococcus aureus FtsZ GTPase activity expressed in Escherichia coli BL21 (DE3) assessed as production of inorganic pho...				Bioorg Med Chem 21: 5673-8 (2013) Article DOI: 10.1016/j.bmc.2013.07.033 BindingDB Entry DOI: 10.7270/Q2057HC4
					More data for this Ligand-Target Pair
Cell division protein FtsZ (Bacillus subtilis)	BDBM50439496 (CHEMBL2418096 | US9169182, J23) Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Inhibition of Bacillus subtilis FtsZ GTPase activity assessed as production of inorganic phosphate measured up to 60 mins by malachite green-phosphom...				Bioorg Med Chem 21: 5673-8 (2013) Article DOI: 10.1016/j.bmc.2013.07.033 BindingDB Entry DOI: 10.7270/Q2057HC4
					More data for this Ligand-Target Pair
Cell division protein FtsZ (Escherichia coli)	BDBM50439496 (CHEMBL2418096 | US9169182, J23) Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of Escherichia coli FtsZ GTPase activity				Eur J Med Chem 95: 1-15 (2015) Article DOI: 10.1016/j.ejmech.2015.03.026 BindingDB Entry DOI: 10.7270/Q2S75J14
					More data for this Ligand-Target Pair
Cell division protein FtsZ (Escherichia coli)	BDBM50439496 (CHEMBL2418096 | US9169182, J23) Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	6.5	25
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION US Patent					Assay Description The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...				US Patent US9169182 (2015) BindingDB Entry DOI: 10.7270/Q22Z149Z
					More data for this Ligand-Target Pair
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50439496 (CHEMBL2418096 | US9169182, J23) Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus FtsZ GTPase activity				Eur J Med Chem 95: 1-15 (2015) Article DOI: 10.1016/j.ejmech.2015.03.026 BindingDB Entry DOI: 10.7270/Q2S75J14
					More data for this Ligand-Target Pair
Cell division protein FtsZ (Staphylococcus aureus)	BDBM50439496 (CHEMBL2418096 | US9169182, J23) Show SMILES COc1cc(C\C=C(\Cl)Cc2cc(O)cc(O)c2)c(OC)cc1Cl Show InChI InChI=1S/C18H18Cl2O4/c1-23-17-10-16(20)18(24-2)8-12(17)3-4-13(19)5-11-6-14(21)9-15(22)7-11/h4,6-10,21-22H,3,5H2,1-2H3/b13-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a	6.5	25
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION US Patent					Assay Description The bacterial cytoskeletal protein FtsZ is a GTPase and has structural homology to the eukaryotic cytoskeletal protein tubulin, but lacks significant...				US Patent US9169182 (2015) BindingDB Entry DOI: 10.7270/Q22Z149Z
					More data for this Ligand-Target Pair