Found 4 hits for monomerid = 50439513 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50439513
(CHEMBL2418353)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOC[C@@H]2C)c2nc(n(CCO)c2n1)C(C)(C)O |r| Show InChI InChI=1S/C24H33N7O4/c1-5-25-23(33)26-17-8-6-16(7-9-17)19-28-20(30-11-13-35-14-15(30)2)18-21(29-19)31(10-12-32)22(27-18)24(3,4)34/h6-9,15,32,34H,5,10-14H2,1-4H3,(H2,25,26,33)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Inhibition of mTOR (unknown origin) |
Bioorg Med Chem Lett 23: 5097-104 (2013)
Article DOI: 10.1016/j.bmcl.2013.07.027 BindingDB Entry DOI: 10.7270/Q2QN687D |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM50439513
(CHEMBL2418353)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOC[C@@H]2C)c2nc(n(CCO)c2n1)C(C)(C)O |r| Show InChI InChI=1S/C24H33N7O4/c1-5-25-23(33)26-17-8-6-16(7-9-17)19-28-20(30-11-13-35-14-15(30)2)18-21(29-19)31(10-12-32)22(27-18)24(3,4)34/h6-9,15,32,34H,5,10-14H2,1-4H3,(H2,25,26,33)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Inhibition of human recombinant mTOR (1360-2549) expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 after 30 mins by L... |
Bioorg Med Chem Lett 23: 5097-104 (2013)
Article DOI: 10.1016/j.bmcl.2013.07.027 BindingDB Entry DOI: 10.7270/Q2QN687D |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50439513
(CHEMBL2418353)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOC[C@@H]2C)c2nc(n(CCO)c2n1)C(C)(C)O |r| Show InChI InChI=1S/C24H33N7O4/c1-5-25-23(33)26-17-8-6-16(7-9-17)19-28-20(30-11-13-35-14-15(30)2)18-21(29-19)31(10-12-32)22(27-18)24(3,4)34/h6-9,15,32,34H,5,10-14H2,1-4H3,(H2,25,26,33)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Displacement of TAMRA-PIP3 from PI3Kdelta GRP-1 pleckstrin homology domain (unknown origin) assessed as formation of 3,4,5-inositoltriphosphate after... |
Bioorg Med Chem Lett 23: 5097-104 (2013)
Article DOI: 10.1016/j.bmcl.2013.07.027 BindingDB Entry DOI: 10.7270/Q2QN687D |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50439513
(CHEMBL2418353)Show SMILES CCNC(=O)Nc1ccc(cc1)-c1nc(N2CCOC[C@@H]2C)c2nc(n(CCO)c2n1)C(C)(C)O |r| Show InChI InChI=1S/C24H33N7O4/c1-5-25-23(33)26-17-8-6-16(7-9-17)19-28-20(30-11-13-35-14-15(30)2)18-21(29-19)31(10-12-32)22(27-18)24(3,4)34/h6-9,15,32,34H,5,10-14H2,1-4H3,(H2,25,26,33)/t15-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description Displacement of TAMRA-PIP3 from PI3Kalpha GRP-1 pleckstrin homology domain (unknown origin) assessed as formation of 3,4,5-inositoltriphosphate after... |
Bioorg Med Chem Lett 23: 5097-104 (2013)
Article DOI: 10.1016/j.bmcl.2013.07.027 BindingDB Entry DOI: 10.7270/Q2QN687D |
More data for this Ligand-Target Pair | |