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SMILES: CC(=O)Nc1nc2ccc(cc2s1)-c1cnc(N)c(c1)C(F)(F)F

InChI Key: InChIKey=WUEXEUOEWYMTKK-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50439726   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM50439726
PNG
(CHEMBL2418948)
Show SMILES CC(=O)Nc1nc2ccc(cc2s1)-c1cnc(N)c(c1)C(F)(F)F
Show InChI InChI=1S/C15H11F3N4OS/c1-7(23)21-14-22-11-3-2-8(5-12(11)24-14)9-4-10(15(16,17)18)13(19)20-6-9/h2-6H,1H3,(H2,19,20)(H,21,22,23)
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Article
PubMed
n/an/a 7.90n/an/an/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of PI3Kalpha (unknown origin) using [gamma33P]ATP as substrate by top counting analysis

Bioorg Med Chem Lett 23: 4652-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.010
BindingDB Entry DOI: 10.7270/Q2NP25T0
More data for this
Ligand-Target Pair