BDBM50441606 CHEMBL2437175

SMILES: Clc1ccc2OC(CNc2c1)C(=O)NNC(=S)NCc1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=AMBNHRKSVDUTMT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50441606   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50441606 (CHEMBL2437175) Show SMILES Clc1ccc2OC(CNc2c1)C(=O)NNC(=S)NCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C23H21ClN4O2S/c24-18-10-11-20-19(12-18)25-14-21(30-20)22(29)27-28-23(31)26-13-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-12,21,25H,13-14H2,(H,27,29)(H2,26,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human recombinant ADAMTS-5 using ARGSVILTV-KPIFEVSPSPL(biotinyl)K as substrate incubated 10 mins prior to substrate addition measured a...				Eur J Med Chem 69: 244-61 (2013) Article DOI: 10.1016/j.ejmech.2013.08.027 BindingDB Entry DOI: 10.7270/Q2J967TM
					More data for this Ligand-Target Pair