BDBM50441609 CHEMBL2437177

SMILES: O=C(COc1cccc2ccccc12)NNC(=S)NCc1ccc(cc1)-c1ccccc1

InChI Key: InChIKey=VXLGCXWTFVIBOF-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50441609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50441609 (CHEMBL2437177) Show SMILES O=C(COc1cccc2ccccc12)NNC(=S)NCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C26H23N3O2S/c30-25(18-31-24-12-6-10-22-9-4-5-11-23(22)24)28-29-26(32)27-17-19-13-15-21(16-14-19)20-7-2-1-3-8-20/h1-16H,17-18H2,(H,28,30)(H2,27,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
INSERM Curated by ChEMBL					Assay Description Inhibition of human recombinant ADAMTS-5 using ARGSVILTV-KPIFEVSPSPL(biotinyl)K as substrate incubated 10 mins prior to substrate addition measured a...				Eur J Med Chem 69: 244-61 (2013) Article DOI: 10.1016/j.ejmech.2013.08.027 BindingDB Entry DOI: 10.7270/Q2J967TM
					More data for this Ligand-Target Pair