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SMILES: FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccccc3)c12

InChI Key: InChIKey=BPHRPHHEZDJQER-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50442791   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50442791
PNG
(CHEMBL2440448)
Show SMILES FC(F)(F)c1cccc2cc3c(nc(=O)[nH]c3=O)n(-c3ccccc3)c12
Show InChI InChI=1S/C18H10F3N3O2/c19-18(20,21)13-8-4-5-10-9-12-15(22-17(26)23-16(12)25)24(14(10)13)11-6-2-1-3-7-11/h1-9H,(H,23,25,26)
PDB
MMDB

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KEGG

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Article
PubMed
n/an/a 1.75E+4n/an/an/an/an/an/a



University of Nottingham

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) assessed as p53 ubiquitination by Western blot analysis

Bioorg Med Chem 21: 6868-77 (2013)


Article DOI: 10.1016/j.bmc.2013.09.038
BindingDB Entry DOI: 10.7270/Q2KS6T01
More data for this
Ligand-Target Pair