Found 10 hits for monomerid = 50442989 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tryptophan 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m... |
Eur J Med Chem 160: 133-145 (2018)
Article DOI: 10.1016/j.ejmech.2018.10.017 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrate |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 2
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.46E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Uncompetitive inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) in presence of va... |
Eur J Med Chem 123: 171-179 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.013 BindingDB Entry DOI: 10.7270/Q2M90BNZ |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 2
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human IDO2 expressed in human U87MG cells assessed as reduction in kynurenine formation using L-tryptophan as substrate aft... |
Eur J Med Chem 123: 171-179 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.013 BindingDB Entry DOI: 10.7270/Q2M90BNZ |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Tryptophan 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 229 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrs |
Eur J Med Chem 160: 133-145 (2018)
Article DOI: 10.1016/j.ejmech.2018.10.017 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.19E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Uncompetitive inhibition of human recombinant IDO1 using L-tryptophan as substrate |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Tryptophan 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 mins |
Eur J Med Chem 160: 133-145 (2018)
Article DOI: 10.1016/j.ejmech.2018.10.017 |
More data for this Ligand-Target Pair | |
Tryptophan 2,3-dioxygenase
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 227 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrs |
Eur J Med Chem 160: 133-145 (2018)
Article DOI: 10.1016/j.ejmech.2018.10.017 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 2
(Homo sapiens (Human)) | BDBM50442989
(CHEMBL3087010)Show InChI InChI=1S/C15H7ClN2O2/c16-9-5-3-7-11-12(9)13(19)14-17-10-6-2-1-4-8(10)15(20)18(11)14/h1-7H | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.34E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human C-terminal His6-tagged IDO2 (14-420 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction in L-kynu... |
Eur J Med Chem 123: 171-179 (2016)
Article DOI: 10.1016/j.ejmech.2016.07.013 BindingDB Entry DOI: 10.7270/Q2M90BNZ |
More data for this Ligand-Target Pair | |