BDBM50444155 CHEMBL3093404

SMILES: CC(O)c1cc(ccc1N1CC[C@@H](C1)Oc1ccc(F)cc1)C(F)(F)F

InChI Key: InChIKey=JTWFOVKRVUEGDP-INSVYWFGSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50444155   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50444155 (CHEMBL3093404) Show SMILES CC(O)c1cc(ccc1N1CC[C@@H](C1)Oc1ccc(F)cc1)C(F)(F)F |r| Show InChI InChI=1S/C19H19F4NO2/c1-12(25)17-10-13(19(21,22)23)2-7-18(17)24-9-8-16(11-24)26-15-5-3-14(20)4-6-15/h2-7,10,12,16,25H,8-9,11H2,1H3/t12?,16-/m0/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.95E+3	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc Curated by ChEMBL					Assay Description Inhibition of recombinant human endothelial lipase using bis-BODIPY-FL C11-PC as substrate preincubated for 30 mins followed by substrate addition by...				Bioorg Med Chem 21: 7724-34 (2013) Article DOI: 10.1016/j.bmc.2013.10.023 BindingDB Entry DOI: 10.7270/Q2P55PZ8
					More data for this Ligand-Target Pair