BDBM50445276 CHEMBL3103917

SMILES: CCOC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1

InChI Key: InChIKey=PVHSBYVFVRQXQK-RIYZIHGNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50445276   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50445276 (CHEMBL3103917) Show SMILES CCOC(=O)N1Cc2cc(ccc2C1=O)-c1ccc(\C=C2\NC(=S)NC2=O)s1 Show InChI InChI=1S/C19H15N3O4S2/c1-2-26-19(25)22-9-11-7-10(3-5-13(11)17(22)24)15-6-4-12(28-15)8-14-16(23)21-18(27)20-14/h3-8H,2,9H2,1H3,(H2,20,21,23,27)/b14-8+	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated f...				J Med Chem 56: 9542-55 (2014) Article DOI: 10.1021/jm401604x BindingDB Entry DOI: 10.7270/Q26Q1ZQ3
					More data for this Ligand-Target Pair