BDBM50445403 CHEMBL3104666

SMILES: CCCC1SC(NC1=O)=Cc1nc2ccc(F)cc2[nH]1

InChI Key: InChIKey=REAKZEFCXBYZMN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50445403   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) (Homo sapiens (Human))	BDBM50445403 (CHEMBL3104666) Show SMILES CCCC1SC(NC1=O)=Cc1nc2ccc(F)cc2[nH]1 |w:9.10| Show InChI InChI=1S/C14H14FN3OS/c1-2-3-11-14(19)18-13(20-11)7-12-16-9-5-4-8(15)6-10(9)17-12/h4-7,11H,2-3H2,1H3,(H,16,17)(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Asahi Kasei Pharma Corporation Curated by ChEMBL					Assay Description Inhibition of human recombinant ADAMTS-5 using interglobular domain peptide of aggrecan after 60 mins by FRET assay				Eur J Med Chem 71: 250-8 (2014) Article DOI: 10.1016/j.ejmech.2013.10.075 BindingDB Entry DOI: 10.7270/Q2F76F15
					More data for this Ligand-Target Pair