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BDBM50446395 CHEMBL3109653

SMILES: Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(n3)C(F)(F)F)c2c(C)n1)C(N)=O

InChI Key: InChIKey=VRKWLYPBGKEJKY-YUELXQCFSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50446395   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Complement factor D


(Homo sapiens (Human))		BDBM50446395
PNG
(CHEMBL3109653)
Show SMILES Cc1cc2c(nn(CC(=O)N3[C@@H]4C[C@@H]4C[C@H]3C(=O)Nc3cccc(n3)C(F)(F)F)c2c(C)n1)C(N)=O |r|
Show InChI InChI=1S/C23H22F3N7O3/c1-10-6-13-19(21(27)35)31-32(20(13)11(2)28-10)9-18(34)33-14-7-12(14)8-15(33)22(36)30-17-5-3-4-16(29-17)23(24,25)26/h3-6,12,14-15H,7-9H2,1-2H3,(H2,27,35)(H,29,30,36)/t12-,14-,15+/m1/s1
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Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human factor D expressed in Escherichia coli using Z-Lys-thiobenzyl and 2,4-dinitrobenzenesulfonyl-fluoresceine as substrat...

ACS Med Chem Lett 5: 106-7 (2014)


Article DOI: 10.1021/ml500037a
BindingDB Entry DOI: 10.7270/Q26D5VG4
More data for this
Ligand-Target Pair