BDBM50446879 CHEMBL3115287

SMILES: OC(=O)CNC(=O)c1c(O)c(cn(Cc2ccccc2)c1=O)C(=O)NCc1ccccc1

InChI Key: InChIKey=KLZXBHCWAHDHCC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50446879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM50446879 (CHEMBL3115287) Show SMILES OC(=O)CNC(=O)c1c(O)c(cn(Cc2ccccc2)c1=O)C(=O)NCc1ccccc1 Show InChI InChI=1S/C23H21N3O6/c27-18(28)12-25-22(31)19-20(29)17(21(30)24-11-15-7-3-1-4-8-15)14-26(23(19)32)13-16-9-5-2-6-10-16/h1-10,14,29H,11-13H2,(H,24,30)(H,25,31)(H,27,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA				J Med Chem 56: 9369-402 (2014) Article DOI: 10.1021/jm400386j BindingDB Entry DOI: 10.7270/Q290258T
					More data for this Ligand-Target Pair