BDBM50446902 CHEMBL3115294

SMILES: COc1ccc(nc1OC)-n1c(=S)[nH]c2sc(C(=O)NCc3ccc(Cl)cc3)c(C)c2c1=O

InChI Key: InChIKey=HZQCGHUXTQUDJR-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50446902   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM50446902 (CHEMBL3115294) Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2sc(C(=O)NCc3ccc(Cl)cc3)c(C)c2c1=O Show InChI InChI=1S/C22H19ClN4O4S2/c1-11-16-20(33-17(11)18(28)24-10-12-4-6-13(23)7-5-12)26-22(32)27(21(16)29)15-9-8-14(30-2)19(25-15)31-3/h4-9H,10H2,1-3H3,(H,24,28)(H,26,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Inhibition of PHD3 in human Hep3B cells assessed as stimulation of EPO release after 48 hrs by ELISA				J Med Chem 56: 9369-402 (2014) Article DOI: 10.1021/jm400386j BindingDB Entry DOI: 10.7270/Q290258T
					More data for this Ligand-Target Pair
Prolyl hydroxylase EGLN3 (Homo sapiens (Human))	BDBM50446902 (CHEMBL3115294) Show SMILES COc1ccc(nc1OC)-n1c(=S)[nH]c2sc(C(=O)NCc3ccc(Cl)cc3)c(C)c2c1=O Show InChI InChI=1S/C22H19ClN4O4S2/c1-11-16-20(33-17(11)18(28)24-10-12-4-6-13(23)7-5-12)26-22(32)27(21(16)29)15-9-8-14(30-2)19(25-15)31-3/h4-9H,10H2,1-3H3,(H,24,28)(H,26,32)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutical Research& Development, LLC Curated by ChEMBL					Assay Description Inhibition of 6His-tagged PHD3 (1 to 239) (unknown origin)-mediated Cy5CODD hydroxylation expressed in Escherichia coli preincubated for 3 mins follo...				J Med Chem 56: 9369-402 (2014) Article DOI: 10.1021/jm400386j BindingDB Entry DOI: 10.7270/Q290258T
					More data for this Ligand-Target Pair