BDBM50447207 CHEMBL3113187::US10752581, Compound 57
SMILES: COc1cccc(CNc2ccc(cc2)S(=O)(=O)Nc2ccc(C)nc2)c1O
InChI Key: InChIKey=AYIYTTKZCABTEC-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Polyunsaturated fatty acid lipoxygenase ALOX12 (Homo sapiens (Human)) | BDBM50447207 (CHEMBL3113187 | US10752581, Compound 57) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Virginia Medical School; The Regents of the University of California Santa; The United States of America Department of Health; Thomas Jefferson University US Patent | Assay Description UV-vis cuvette-based assay. | US Patent US10752581 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polyunsaturated fatty acid lipoxygenase ALOX12 (Homo sapiens (Human)) | BDBM50447207 (CHEMBL3113187 | US10752581, Compound 57) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institutes of Health Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysis | J Med Chem 57: 495-506 (2014) Article DOI: 10.1021/jm4016476 BindingDB Entry DOI: 10.7270/Q27082XR | |||||||||||
More data for this Ligand-Target Pair |