BDBM50447563 CHEMBL3112703
SMILES: CCn1cc(C(=O)Nc2cccnc2)c(C)n1
InChI Key: InChIKey=GRYJMSHNDHNTFC-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50447563 (CHEMBL3112703) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Inhibition of full length C-terminal His6-tagged human NAMPT expressed in Escherichia coli Rosetta (DE3) cells using PRPP/NAM as substrate/cofactor p... | Bioorg Med Chem Lett 24: 954-62 (2014) Article DOI: 10.1016/j.bmcl.2013.12.062 BindingDB Entry DOI: 10.7270/Q2RV0Q50 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human)) | BDBM50447563 (CHEMBL3112703) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.33E+5 | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis | Bioorg Med Chem Lett 24: 954-62 (2014) Article DOI: 10.1016/j.bmcl.2013.12.062 BindingDB Entry DOI: 10.7270/Q2RV0Q50 | |||||||||||
More data for this Ligand-Target Pair |