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SMILES: Cc1ncc(C(=O)Nc2cccnc2)n1C

InChI Key: InChIKey=ARUNAMRHCYQJBF-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50447565   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50447565 (CHEMBL3112701) Show SMILES Cc1ncc(C(=O)Nc2cccnc2)n1C Show InChI InChI=1S/C11H12N4O/c1-8-13-7-10(15(8)2)11(16)14-9-4-3-5-12-6-9/h3-7H,1-2H3,(H,14,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of full length C-terminal His6-tagged human NAMPT expressed in Escherichia coli Rosetta (DE3) cells using PRPP/NAM as substrate/cofactor p...				Bioorg Med Chem Lett 24: 954-62 (2014) Article DOI: 10.1016/j.bmcl.2013.12.062 BindingDB Entry DOI: 10.7270/Q2RV0Q50
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50447565 (CHEMBL3112701) Show SMILES Cc1ncc(C(=O)Nc2cccnc2)n1C Show InChI InChI=1S/C11H12N4O/c1-8-13-7-10(15(8)2)11(16)14-9-4-3-5-12-6-9/h3-7H,1-2H3,(H,14,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>5.00E+5	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis				Bioorg Med Chem Lett 24: 954-62 (2014) Article DOI: 10.1016/j.bmcl.2013.12.062 BindingDB Entry DOI: 10.7270/Q2RV0Q50
					More data for this Ligand-Target Pair