BDBM50447575 CHEMBL3112691

SMILES: Cn1ccnc1C(=O)Nc1cccnc1

InChI Key: InChIKey=QXFJLMJZUNRKRT-UHFFFAOYSA-N

Data: 1 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50447575   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50447575 (CHEMBL3112691) Show SMILES Cn1ccnc1C(=O)Nc1cccnc1 Show InChI InChI=1S/C10H10N4O/c1-14-6-5-12-9(14)10(15)13-8-3-2-4-11-7-8/h2-7H,1H3,(H,13,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of full length C-terminal His6-tagged human NAMPT expressed in Escherichia coli Rosetta (DE3) cells using PRPP/NAM as substrate/cofactor p...				Bioorg Med Chem Lett 24: 954-62 (2014) Article DOI: 10.1016/j.bmcl.2013.12.062 BindingDB Entry DOI: 10.7270/Q2RV0Q50
					More data for this Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (Homo sapiens (Human))	BDBM50447575 (CHEMBL3112691) Show SMILES Cn1ccnc1C(=O)Nc1cccnc1 Show InChI InChI=1S/C10H10N4O/c1-14-6-5-12-9(14)10(15)13-8-3-2-4-11-7-8/h2-7H,1H3,(H,13,15)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.29E+5	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to N-terminal His6-tagged/biotinylated C-terminal Avi-tagged human NAMPT (2 to 491) by SPR analysis				Bioorg Med Chem Lett 24: 954-62 (2014) Article DOI: 10.1016/j.bmcl.2013.12.062 BindingDB Entry DOI: 10.7270/Q2RV0Q50
					More data for this Ligand-Target Pair