BDBM50448048 CHEMBL3115504

SMILES: COc1ccc(cc1)-c1ccc2nc3cncc(\C=C\c4ccccc4)n3c2c1

InChI Key: InChIKey=KYRYNOGFQDOUCA-YRNVUSSQSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50448048   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50448048 (CHEMBL3115504) Show SMILES COc1ccc(cc1)-c1ccc2nc3cncc(\C=C\c4ccccc4)n3c2c1 Show InChI InChI=1S/C25H19N3O/c1-29-22-12-8-19(9-13-22)20-10-14-23-24(15-20)28-21(16-26-17-25(28)27-23)11-7-18-5-3-2-4-6-18/h2-17H,1H3/b11-7+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lyon Curated by ChEMBL					Assay Description Inhibition of recombinant wild type ALK catalytic domain (1064 to 1427) (unknown origin) expressed in baculovirus expression system using ARDIYRASFFR...				Bioorg Med Chem 22: 1303-12 (2014) Article DOI: 10.1016/j.bmc.2014.01.007 BindingDB Entry DOI: 10.7270/Q2NZ894Q
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor/Nucleophosmin (Homo sapiens (Human))	BDBM50448048 (CHEMBL3115504) Show SMILES COc1ccc(cc1)-c1ccc2nc3cncc(\C=C\c4ccccc4)n3c2c1 Show InChI InChI=1S/C25H19N3O/c1-29-22-12-8-19(9-13-22)20-10-14-23-24(15-20)28-21(16-26-17-25(28)27-23)11-7-18-5-3-2-4-6-18/h2-17H,1H3/b11-7+	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lyon Curated by ChEMBL					Assay Description Inhibition of NPM/ALK (unknown origin) transfected in mouse BAF3 cells assessed as cell growth inhibition after 72 hrs by [3H]-thymidine incorporatio...				Bioorg Med Chem 22: 1303-12 (2014) Article DOI: 10.1016/j.bmc.2014.01.007 BindingDB Entry DOI: 10.7270/Q2NZ894Q
					More data for this Ligand-Target Pair