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SMILES: O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)[C@@H]1C[C@H]1c1cccnc1

InChI Key: InChIKey=DKVMCAUOPOZWRV-LEWJYISDSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50448637   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))		BDBM50448637
PNG
(CHEMBL3127527)
Show SMILES O=C(NCc1ccc(cc1)S(=O)(=O)c1ccccc1)[C@@H]1C[C@H]1c1cccnc1 |r|
Show InChI InChI=1S/C22H20N2O3S/c25-22(21-13-20(21)17-5-4-12-23-15-17)24-14-16-8-10-19(11-9-16)28(26,27)18-6-2-1-3-7-18/h1-12,15,20-21H,13-14H2,(H,24,25)/t20-,21+/m0/s1
PDB
MMDB

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Article
PubMed
n/an/a 1.50E+3n/an/an/an/an/an/a



Genentech

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged human full-length NAMPT expressed in Escherichia coli Rosetta DE3 using nicotinamide as substrate preincubated fo...

J Med Chem 57: 770-92 (2014)


Article DOI: 10.1021/jm4015108
BindingDB Entry DOI: 10.7270/Q2BC412B
More data for this
Ligand-Target Pair