BDBM50449064 CHEMBL3126941

SMILES: CC(C)(CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F)c1cc(F)ccc1O

InChI Key: InChIKey=RCQVRWJFEKOHOS-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50449064   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Progesterone receptor (Homo sapiens (Human))	BDBM50449064 (CHEMBL3126941) Show SMILES CC(C)(CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F)c1cc(F)ccc1O Show InChI InChI=1S/C19H19F4N3O2/c1-17(2,13-5-11(20)3-4-16(13)27)9-18(28,19(21,22)23)7-12-6-14-15(26-12)8-24-10-25-14/h3-6,8,10,26-28H,7,9H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Competitive binding affinity to progesterone receptor (unknown origin) expressed in baculovirus-infected cell system after 1 hr by fluorescence polar...				J Med Chem 57: 1583-98 (2014) Article DOI: 10.1021/jm4019178 BindingDB Entry DOI: 10.7270/Q23N24W5
					More data for this Ligand-Target Pair
Mineralocorticoid receptor (Homo sapiens (Human))	BDBM50449064 (CHEMBL3126941) Show SMILES CC(C)(CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F)c1cc(F)ccc1O Show InChI InChI=1S/C19H19F4N3O2/c1-17(2,13-5-11(20)3-4-16(13)27)9-18(28,19(21,22)23)7-12-6-14-15(26-12)8-24-10-25-14/h3-6,8,10,26-28H,7,9H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Competitive binding affinity to mineralocorticoid receptor (unknown origin) expressed in baculovirus-infected cell system after 1 hr by fluorescence ...				J Med Chem 57: 1583-98 (2014) Article DOI: 10.1021/jm4019178 BindingDB Entry DOI: 10.7270/Q23N24W5
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50449064 (CHEMBL3126941) Show SMILES CC(C)(CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F)c1cc(F)ccc1O Show InChI InChI=1S/C19H19F4N3O2/c1-17(2,13-5-11(20)3-4-16(13)27)9-18(28,19(21,22)23)7-12-6-14-15(26-12)8-24-10-25-14/h3-6,8,10,26-28H,7,9H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Transrepression activity at glucocorticoid receptor in human fibroblasts assessed as inhibition of IL-1-induced IL-6 production after 18 to 24 hrs				J Med Chem 57: 1583-98 (2014) Article DOI: 10.1021/jm4019178 BindingDB Entry DOI: 10.7270/Q23N24W5
					More data for this Ligand-Target Pair
Glucocorticoid receptor (Homo sapiens (Human))	BDBM50449064 (CHEMBL3126941) Show SMILES CC(C)(CC(O)(Cc1cc2ncncc2[nH]1)C(F)(F)F)c1cc(F)ccc1O Show InChI InChI=1S/C19H19F4N3O2/c1-17(2,13-5-11(20)3-4-16(13)27)9-18(28,19(21,22)23)7-12-6-14-15(26-12)8-24-10-25-14/h3-6,8,10,26-28H,7,9H2,1-2H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL					Assay Description Competitive binding affinity to glucocorticoid receptor (unknown origin) expressed in baculovirus-infected cell system after 1 hr by fluorescence pol...				J Med Chem 57: 1583-98 (2014) Article DOI: 10.1021/jm4019178 BindingDB Entry DOI: 10.7270/Q23N24W5
					More data for this Ligand-Target Pair