BDBM50449754 CHEMBL4167553

SMILES: ONC(=O)CCNc1cc(Cl)cc(Cl)c1

InChI Key: InChIKey=KRPIERJODNQEGY-UHFFFAOYSA-N

Data: 2 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50449754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50449754 (CHEMBL4167553) Show SMILES ONC(=O)CCNc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C9H10Cl2N2O2/c10-6-3-7(11)5-8(4-6)12-2-1-9(14)13-15/h3-5,12,15H,1-2H2,(H,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	152	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Mixed type non-competitive inhibition of urease in Helicobacter pylori ATCC 43504 assessed as enzyme-substrate-inhibitor complex constant preincubate...				Eur J Med Chem 156: 126-136 (2018) Article DOI: 10.1016/j.ejmech.2018.06.065 BindingDB Entry DOI: 10.7270/Q2N87DBC
					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50449754 (CHEMBL4167553) Show SMILES ONC(=O)CCNc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C9H10Cl2N2O2/c10-6-3-7(11)5-8(4-6)12-2-1-9(14)13-15/h3-5,12,15H,1-2H2,(H,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Mixed type non-competitive inhibition of urease in Helicobacter pylori ATCC 43504 assessed as reduction in ammonia production preincubated for 1.5 hr...				Eur J Med Chem 156: 126-136 (2018) Article DOI: 10.1016/j.ejmech.2018.06.065 BindingDB Entry DOI: 10.7270/Q2N87DBC
					More data for this Ligand-Target Pair
Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50449754 (CHEMBL4167553) Show SMILES ONC(=O)CCNc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C9H10Cl2N2O2/c10-6-3-7(11)5-8(4-6)12-2-1-9(14)13-15/h3-5,12,15H,1-2H2,(H,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of urease in Helicobacter pylori ATCC 43504 assessed as reduction in ammonia production preincubated for 1.5 hrs by indophenol method				Eur J Med Chem 156: 126-136 (2018) Article DOI: 10.1016/j.ejmech.2018.06.065 BindingDB Entry DOI: 10.7270/Q2N87DBC
					More data for this Ligand-Target Pair
Urease subunit alpha/Urease subunit beta (Helicobacter pylori (strain ATCC 700392 / 26695) (...)	BDBM50449754 (CHEMBL4167553) Show SMILES ONC(=O)CCNc1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C9H10Cl2N2O2/c10-6-3-7(11)5-8(4-6)12-2-1-9(14)13-15/h3-5,12,15H,1-2H2,(H,13,14)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Jishou University Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori ATCC 43504 urease assessed as reduction in ammonia production preincubated for 1.5 hrs under cell free condition by...				Eur J Med Chem 156: 126-136 (2018) Article DOI: 10.1016/j.ejmech.2018.06.065 BindingDB Entry DOI: 10.7270/Q2N87DBC
					More data for this Ligand-Target Pair