| Reaction Details |
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 | Report a problem with these data |
| Target | Urease subunit alpha/beta |
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| Ligand | BDBM50449754 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1740613 (CHEMBL4156363) |
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| IC50 | 43±n/a nM |
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| Citation |  Liu, Q; Shi, WK; Ren, SZ; Ni, WW; Li, WY; Chen, HM; Liu, P; Yuan, J; He, XS; Liu, JJ; Cao, P; Yang, PZ; Xiao, ZP; Zhu, HL Arylamino containing hydroxamic acids as potent urease inhibitors for the treatment of Helicobacter pylori infection. Eur J Med Chem156:126-136 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Urease subunit alpha/beta |
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| Name: | Urease subunit alpha/beta |
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| Synonyms: | Urease subunit alpha/Urease subunit beta |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 1740613 |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Urease subunit beta |
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| Synonyms: | 3.5.1.5 | URE1_HELPY | Urea amidohydrolase subunit beta | Urease subunit beta | hpuB | ureB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61676.43 |
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| Organism: | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
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| Description: | ChEMBL_117195 |
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| Residue: | 569 |
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| Sequence: | MKKISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSNN
PSKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEA
LAGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLK
WMLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADK
YDVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPAST
NPTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITS
SDSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGIS
EYVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFA
HHGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCRNITKKDMQFNDTTAHIEVNP
ETYHVFVDGKEVTSKPANKVSLAQLFSIF
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| Component 2 |
| Name: | Urease subunit alpha |
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| Synonyms: | URE23_HELPY | Urease | hpuA | ureA |
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| Type: | Enzyme |
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| Mol. Mass.: | 26545.30 |
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| Organism: | Helicobacter pylori |
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| Description: | P14916 |
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| Residue: | 238 |
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| Sequence: | MKLTPKELDKLMLHYAGELAKKRKEKGIKLNYVEAVALISAHIMEEARAGKKTAAELMQE
GRTLLKPDDVMDGVASMIHEVGIEAMFPDGTKLVTVHTPIEANGKLVPGELFLKNEDITI
NEGKKAVSVKVKNVGDRPVQIGSHFHFFEVNRCLDFDREKTFGKRLDIASGTAVRFEPGE
EKSVELIDIGGNRRIFGFNALVDRQADNESKKIALHRAKERGFHGAKSDDNYVKTIKE
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| BDBM50449754 |
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| n/a |
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| Name | BDBM50449754 |
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| Synonyms: | CHEMBL4167553 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10Cl2N2O2 |
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| Mol. Mass. | 249.094 |
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| SMILES | ONC(=O)CCNc1cc(Cl)cc(Cl)c1 |
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| Structure | 
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